Vav Proteins in Neutrophils Are Required for FcγR-Mediated Signaling to Rac GTPases and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Component p40(phox)
Phagocytes generate reactive oxygen species, the regulation of which is important in eliminating ingested microbes while limiting tissue damage. Clustering of FcgammaRs results in the activation of Vav proteins, Rho/Rac guanine nucleotide exchange factors, and results in robust superoxide generation...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2006
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| 在線閱讀: | https://doi.org/10.4049/jimmunol.177.9.6388 https://journals.aai.org/jimmunol/article-pdf/177/9/6388/1229747/zim02106006388.pdf |
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