Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity
Hematopoietic prostaglandin D 2 synthase (hPGD 2 S) metabolizes cyclooxygenase-derived prostaglandin (PG) H 2 to PGD 2 , which is dehydrated to cyclopentenone PGs, including 15-deoxy-Δ 12,14 -PGJ 2 (15d-PGJ 2 ). PGD 2 acts through two receptors (DP1 and DP2/CRTH2), whereas 15d-PGJ 2 can activate per...
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| Glavni autori: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | engleski |
| Izdano: |
2006
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| Online pristup: | https://doi.org/10.1073/pnas.0507175103 |
| Oznake: |
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