T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6

An important signaling pathway for the differentiation of T helper type 2 (TH2) cells from uncommitted CD4 T cell precursors is activation of the STAT6 transcription factor by interleukin 4 (IL-4). The protooncogene BCL-6 is also involved in TH2 differentiation, as BCL-6 −/− mice develop an inflamma...

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Main Authors: Alexander L. Dent, Jane Hu‐Li, William E. Paul, Louis M. Staudt
格式: Artigo
語言:英语
出版: 1998
在線閱讀:https://doi.org/10.1073/pnas.95.23.13823
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