Basal Core Promoter and Precore Mutations in the Hepatitis B Virus Genome Enhance Replication Efficacy of Lamivudine-Resistant Mutants
ABSTRACT During chronic hepatitis B virus (HBV) infection, mutations in the precore (PC) or basal core promoter (BCP) region affecting HBV e antigen (HBeAg) expression occur commonly and represent the predominant virus species in patients with HBeAg-negative chronic hepatitis B. The PC mutation (G18...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2004
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| Online Access: | https://doi.org/10.1128/jvi.78.16.8524-8535.2004 |
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