A Single β-Amino Acid Substitution to Angiotensin II Confers AT <sub>2</sub> Receptor Selectivity and Vascular Function

A Single β-Amino Acid Substitution to Angiotensin II Confers AT <sub>2</sub> Receptor Selectivity and Vascular Function

Novel AT(2)R ligands were designed by substituting individual β-amino acid in the sequence of the native ligand angiotensin II (Ang II). Relative ATR selectivity and functional vascular assays (in vitro AT(2)R-mediated vasorelaxation and in vivo vasodepressor action) were determined. In competition...

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Autors principals: Emma S. Jones, Mark P. Del Borgo, Julian F. Kirsch, Daniel Clayton, Sanja Bosnyak, Iresha Welungoda, Nicholas Hausler, Sharon Unabia, Patrick Perlmutter, Walter G. Thomas, Marie‐Isabel Aguilar, Robert E. Widdop
Format: Artigo
Idioma:anglès
Publicat: 2011
Accés en línia:https://doi.org/10.1161/hypertensionaha.110.164301
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https://doi.org/10.1161/hypertensionaha.110.164301

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