Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment

We have demonstrated previously that the complex bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N']copper(II), named [Cu(isaepy)(2)], induces AMPK (AMP-activated protein kinase)-dependent/p53-mediated apoptosis in tumour cells by targeting mitochondria. In the present study, we found that...

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Main Authors: Giuseppe Filomeni, Simone Cardaci, Ana Maria da Costa Ferreira, Giuseppe Rotilio, Maria Rosa Ciriolo
格式: Artigo
語言:英语
出版: 2011
在線閱讀:https://doi.org/10.1042/bj20110510
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