Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment

We have demonstrated previously that the complex bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N']copper(II), named [Cu(isaepy)(2)], induces AMPK (AMP-activated protein kinase)-dependent/p53-mediated apoptosis in tumour cells by targeting mitochondria. In the present study, we found that...

詳細記述

保存先:
書誌詳細
主要な著者: Giuseppe Filomeni, Simone Cardaci, Ana Maria da Costa Ferreira, Giuseppe Rotilio, Maria Rosa Ciriolo
フォーマット: Artigo
言語:英語
出版事項: 2011
オンライン・アクセス:https://doi.org/10.1042/bj20110510
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!