Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 <sup>Shc</sup> -Regulated Reactive Oxygen Species

Objective— Reactive oxygen species regulate canonical Wnt signaling. However, the role of the redox regulatory protein p66 Shc in the canonical Wnt pathway is not known. We investigated whether p66 Shc is essential for canonical Wnt signaling in the endothelium and determined whether the canonical W...

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Autors principals: Ajit Vikram, Young‐Rae Kim, Santosh Kumar, Asma Naqvi, Timothy A. Hoffman, Ajay Kumar, Francis J. Miller, Cuk‐Seong Kim, Kaikobad Irani
Format: Artigo
Idioma:anglès
Publicat: 2014
Accés en línia:https://doi.org/10.1161/atvbaha.114.304338
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