Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
Activation of the transcription factor NF-kappaB/Rel has been shown to be involved in inflammatory disease. Here we studied the role of RelA/p65, the main transactivating subunit, during acute pancreatitis using a Cre-loxP strategy. Selective truncation of the rela gene in pancreatic exocrine cells...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2007
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| Online adgang: | https://doi.org/10.1172/jci29882 http://www.jci.org/articles/view/29882/files/pdf |
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