Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

Cytotoxic T lymphocytes (CTL) can trigger an apoptotic signal through the Fas receptor or by the exocytosis of granzyme B and perforin. Caspase activation is an important component of both pathways. Granzyme B, a serine proteinase contained in granules, has been shown to proteolytically process and...

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Hlavní autoři: Michèle Barry, Jeffrey A. Heibein, Michael J. Pinkoski, Siow‐Fong Lee, Richard W. Moyer, Douglas R. Green, R. Chris Bleackley
Médium: Artigo
Jazyk:angličtina
Vydáno: 2000
On-line přístup:https://doi.org/10.1128/mcb.20.11.3781-3794.2000
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https://doi.org/10.1128/mcb.20.11.3781-3794.2000

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