Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system

Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the development of therapy-resistant tumours, we established a new tumour model which closely resembles the situation in patients who receive androge...

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Main Authors: Zoran Čulig, Jens Hoffmann, Martin Erdel, Iris E. Eder, Alfred Hobisch, A Hittmair, G. Bartsch, Gerd Utermann, M. R. Schneider, Karsten Parczyk, Helmut Klocker
格式: Artigo
语言:英语
出版: 1999
在线阅读:https://doi.org/10.1038/sj.bjc.6690684
https://www.nature.com/articles/6690684.pdf
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