Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

Glioblastoma (GBM) is the most common malignant brain tumor in adults and is associated with a poor prognosis. Cytotoxic T lymphocyte antigen -4 (CTLA-4) blocking antibodies have demonstrated an ability to generate robust antitumor immune responses against a variety of solid tumors. 4-1BB (CD137) is...

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Main Authors: Zineb Belcaid, Jillian Phallen, Jing Zeng, Alfred P. See, Dimitrios Mathios, C. Gottschalk, Sarah E. Nicholas, M. Kellett, Jacob Ruzevick, Christopher M. Jackson, Emilia Albesiano, Nicholas M. Durham, Xiaobu Ye, Phuoc T. Tran, Betty Tyler, John Wong, Henry Brem, Drew M. Pardoll, Charles G. Drake, Michael Lim
Format: Artigo
Language:English
Published: 2014
Online Access:https://doi.org/10.1371/journal.pone.0101764
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101764&type=printable
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https://doi.org/10.1371/journal.pone.0101764
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101764&type=printable

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