Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the aging process. In the present study, we used PCR amplification of full-length mitochondrial genomes from...

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Main Authors: Konstantin Khrapko, Natalya D. Bodyak, William G. Thilly, Nathalie J. van Orsouw, Xianfeng Zhang, Hilary A. Coller, Thomas T. Perls, Melissa P. Upton, Jan Vijg, Jeanne Y. Wei
Format: Artigo
Language:English
Published: 1999
Online Access:https://doi.org/10.1093/nar/27.11.2434
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https://doi.org/10.1093/nar/27.11.2434

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