Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the aging process. In the present study, we used PCR amplification of full-length mitochondrial genomes from...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Konstantin Khrapko, Natalya D. Bodyak, William G. Thilly, Nathalie J. van Orsouw, Xianfeng Zhang, Hilary A. Coller, Thomas T. Perls, Melissa P. Upton, Jan Vijg, Jeanne Y. Wei
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 1999
Mynediad Ar-lein:https://doi.org/10.1093/nar/27.11.2434
Tagiau: Ychwanegu Tag
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Rhyngrwyd

https://doi.org/10.1093/nar/27.11.2434

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