Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia
Poly(ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP by free radical-damaged DNA plays a pivotal role in mediating ischemia–reperfusion injury. The excessive activation of P...
Збережено в:
| Автори: | , , , , , |
|---|---|
| Формат: | Artigo |
| Мова: | Англійська |
| Опубліковано: |
1999
|
| Онлайн доступ: | https://doi.org/10.1016/s0006-8993(99)01335-9 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|