Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia
Poly(ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP by free radical-damaged DNA plays a pivotal role in mediating ischemia–reperfusion injury. The excessive activation of P...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| Online-Zugang: | https://doi.org/10.1016/s0006-8993(99)01335-9 |
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