Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia

Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia

Poly(ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP by free radical-damaged DNA plays a pivotal role in mediating ischemia–reperfusion injury. The excessive activation of P...

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Hlavní autoři: Kazushi Takahashi, Andrew A. Pieper, Sidney Croul, Jie Zhang, Solomon H. Snyder, Joel Greenberg
Médium: Artigo
Jazyk:angličtina
Vydáno: 1999
On-line přístup:https://doi.org/10.1016/s0006-8993(99)01335-9
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https://doi.org/10.1016/s0006-8993(99)01335-9

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