HIF1 regulates WSB‐1 expression to promote hypoxia‐induced chemoresistance in hepatocellular carcinoma cells

HIF1 regulates WSB‐1 expression to promote hypoxia‐induced chemoresistance in hepatocellular carcinoma cells

WSB-1 is involved in DNA damage response by targeting homeodomain-interacting protein kinase 2 (HIPK2) for ubiquitination and degradation. Here, we report that hypoxia significantly up-regulates the expression of WSB-1 in human hepatocellular carcinoma (HCC) cells. We also provide evidence that WSB-...

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Hlavní autoři: Ying Tong, Qigen Li, Tianyu Xing, Ming Zhang, Jianjun Zhang, Qiang Xia
Médium: Artigo
Jazyk:angličtina
Vydáno: 2013
On-line přístup:https://doi.org/10.1016/j.febslet.2013.06.017
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2013.06.017
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https://doi.org/10.1016/j.febslet.2013.06.017
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2013.06.017

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