The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in the pancreatic beta cells are decisive for their survival or death in diabetes. We have used RNA sequencing (R...

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Bibliographic Details
Main Authors: Décio L. Eizirik, Michael Sammeth, Thomas Bouckenooghe, Guy Bottu, Giorgia Sisino, Mariana Igoillo‐Esteve, Fernanda Ortis, Izortze Santín, Máikel L. Colli, Jenny Barthson, Luc Bouwens, Linda Hughes, Lorna Gregory, Gerton Lunter, Lorella Marselli, Piero Marchetti, Mark I. McCarthy, Miriam Cnop
Format: Artigo
Language:English
Published: 2012
Online Access:https://doi.org/10.1371/journal.pgen.1002552
https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002552&type=printable
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