A missense mutation in <i>CLIC2</i> associated with intellectual disability is predicted by <i>in silico</i> modeling to affect protein stability and dynamics

Large-scale next generation resequencing of X chromosome genes identified a missense mutation in the CLIC2 gene on Xq28 in a male with X-linked intellectual disability (XLID) and not found in healthy individuals. At the same time, numerous nsSNPs (nonsynonomous SNP) have been reported in the CLIC2 g...

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Библиографические подробности
Главные авторы: Shawn Witham, Kyoko Takano, Charles E. Schwartz, Emil Alexov
Формат: Artigo
Язык:английский
Опубликовано: 2011
Online-ссылка:https://doi.org/10.1002/prot.23065
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