Prevention of Plasticity of Endocannabinoid Signaling Inhibits Persistent Limbic Hyperexcitability Caused by Developmental Seizures

Depolarization-induced suppression of inhibition (DSI) is an endocannabinoid-mediated short-term plasticity mechanism that couples postsynaptic Ca 2+ rises to decreased presynaptic GABA release. Whether the gain of this retrograde synaptic mechanism is subject to long-term modulation by glutamatergi...

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Auteurs principaux: Kang Chen, Axel Neu, Allyson Howard, Csaba Földy, Julio Echegoyen, Lutz G.W. Hilgenberg, Martin Smith, Ken Mackie, Iván Soltész
Format: Artigo
Langue:anglais
Publié: 2007
Accès en ligne:https://doi.org/10.1523/jneurosci.3966-06.2007
https://www.jneurosci.org/content/jneuro/27/1/46.full.pdf
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