Translation Initiation Control by Heme-Regulated Eukaryotic Initiation Factor 2α Kinase in Erythroid Cells under Cytoplasmic Stresses

AbstractCytoplasmic stresses, including heat shock, osmotic stress, and oxidative stress, cause rapid inhibition of protein synthesis in cells through phosphorylation of eukaryotic initiation factor 2α (eIF2α) by eIF2α kinases. We have investigated the role of heme-regulated inhibitor (HRI), a heme-...

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Main Authors: Linrong Lu, Anping Han, Jane-Jane Chen
格式: Artigo
语言:英语
出版: 2001
在线阅读:https://doi.org/10.1128/mcb.21.23.7971-7980.2001
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