Translation Initiation Control by Heme-Regulated Eukaryotic Initiation Factor 2α Kinase in Erythroid Cells under Cytoplasmic Stresses
AbstractCytoplasmic stresses, including heat shock, osmotic stress, and oxidative stress, cause rapid inhibition of protein synthesis in cells through phosphorylation of eukaryotic initiation factor 2α (eIF2α) by eIF2α kinases. We have investigated the role of heme-regulated inhibitor (HRI), a heme-...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2001
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| Online Access: | https://doi.org/10.1128/mcb.21.23.7971-7980.2001 |
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