Tryptophan at the transmembrane–cytosolic junction modulates thrombopoietin receptor dimerization and activation
Dimerization of single-pass membrane receptors is essential for activation. In the human thrombopoietin receptor (TpoR), a unique amphipathic RWQFP motif separates the transmembrane (TM) and intracellular domains. Using a combination of mutagenesis, spectroscopy, and biochemical assays, we show that...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2013
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| Online Access: | https://doi.org/10.1073/pnas.1211560110 https://www.pnas.org/content/pnas/110/7/2540.full.pdf |
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