Antitumor Efficacy of a Monoclonal Antibody That Inhibits the Activity of Cancer-Associated Carbonic Anhydrase XII
Carbonic anhydrase XII (CA XII) is a membrane-tethered cell surface enzyme that is highly expressed on many human tumor cells. Carbonic anhydrase members in this class of exofacial molecules facilitate tumor metabolism by facilitating CO2 venting and intracellular pH regulation. Accordingly, inhibit...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2013
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| Online Access: | https://doi.org/10.1158/0008-5472.can-13-1110 |
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