Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)
The poly(ADP-ribose) (PAR) post-translational modification is essential for diverse cellular functions, including regulation of transcription, response to DNA damage, and mitosis. Cellular PAR is predominantly synthesized by the enzyme poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 is a critical nod...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2012
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| Online Access: | https://doi.org/10.1021/cb200506t |
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