AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
AbstractAKT is a key serine/threonine kinase in the PTEN/PI3K/AKT pathway1 and activation of AKT is often observed in human cancers. To explore the role of AKT in cell survival in different tumor cells, we tested 20 human tumor cell lines for response to knockdown of AKT by small interference RNA (s...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2007
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| On-line přístup: | https://doi.org/10.4161/cbt.6.5.3995 https://www.tandfonline.com/doi/pdf/10.4161/cbt.6.5.3995?needAccess=true |
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