Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex
The endoplasmic reticulum Ca(2+)-sensing STIM proteins mediate Ca(2+) entry signals by coupling to activate plasma membrane Orai channels. We reveal that STIM-Orai coupling is rapidly blocked by hypoxia and the ensuing decrease in cytosolic pH. In smooth muscle cells or HEK293 cells coexpressing STI...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | inglés |
| Publicado: |
2011
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| Acceso en línea: | https://doi.org/10.1074/jbc.m111.303081 http://www.jbc.org/article/S0021925820655272/pdf |
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