Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex

Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex

The endoplasmic reticulum Ca(2+)-sensing STIM proteins mediate Ca(2+) entry signals by coupling to activate plasma membrane Orai channels. We reveal that STIM-Orai coupling is rapidly blocked by hypoxia and the ensuing decrease in cytosolic pH. In smooth muscle cells or HEK293 cells coexpressing STI...

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Bibliografiska uppgifter
Huvudupphovsmän:	Salvatore Mancarella, Youjun Wang, Xiaoxiang Deng, Gavin Landesberg, Rosario Scalia, Reynold A. Panettieri, Karthik Mallilankaraman, Xiang D. Tang, Muniswamy Madesh, Donald L. Gill
Materialtyp:	Artigo
Språk:	engelska
Publicerad:	2011
Länkar:	https://doi.org/10.1074/jbc.m111.303081 http://www.jbc.org/article/S0021925820655272/pdf
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