Zoledronic Acid Potentiates mTOR Inhibition and Abolishes the Resistance of Osteosarcoma Cells to RAD001 (Everolimus): Pivotal Role of the Prenylation Process

Zoledronic Acid Potentiates mTOR Inhibition and Abolishes the Resistance of Osteosarcoma Cells to RAD001 (Everolimus): Pivotal Role of the Prenylation Process

Abstract Despite recent improvements in therapeutic management of osteosarcoma, ongoing challenges in improving the response to chemotherapy warrants new strategies still needed to improve overall patient survival. In this study, we investigated in vivo the effects of RAD001 (Everolimus), a new oral...

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Hlavní autoři: Gatien Moriceau, Benjamin Ory, Laura Mitrofan, Chiara Riganti, Frédéric Blanchard, Régis Brion, Céline Charrier, Séverine Battaglia, Paul Pilet, Marc G. Denis, Leonard D. Shultz, Jukka Mönkkönen, Françoise Rédiní, Dominique Heymann
Médium: Artigo
Jazyk:angličtina
Vydáno: 2010
On-line přístup:https://doi.org/10.1158/0008-5472.can-10-0578
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https://doi.org/10.1158/0008-5472.can-10-0578

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