Large deletions of the APC gene in 15% of mutation‐negative patients with classical polyposis (FAP): A Belgian study

Germline mutations of the APC gene are responsible for familial adenomatous polyposis (FAP). Most of the mutations are protein truncating mutations and are spread over the coding region. Rare whole-gene deletions or exonic deletions have been described. From a series of 85 patients clinically diagno...

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Main Authors: G Michils, Sabine Tejpar, Ronald Thoelen, Eric Van Cutsem, Joris Vermeesch, Jean‐Pierre Fryns, Eric Legius, Gert Matthijs
格式: Artigo
語言:英语
出版: 2005
在線閱讀:https://doi.org/10.1002/humu.20122
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