Large deletions of the APC gene in 15% of mutation‐negative patients with classical polyposis (FAP): A Belgian study

Germline mutations of the APC gene are responsible for familial adenomatous polyposis (FAP). Most of the mutations are protein truncating mutations and are spread over the coding region. Rare whole-gene deletions or exonic deletions have been described. From a series of 85 patients clinically diagno...

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Main Authors: G Michils, Sabine Tejpar, Ronald Thoelen, Eric Van Cutsem, Joris Vermeesch, Jean‐Pierre Fryns, Eric Legius, Gert Matthijs
Format: Artigo
Jezik:angleščina
Izdano: 2005
Online dostop:https://doi.org/10.1002/humu.20122
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