Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms including mice, flies, and nematodes. In this study, we show that transgenic expression of Sirtuin-1 induces autophagy in human cells in vitro and in Caenorhabditis elegans in vivo. The knockdow...
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| Main Authors: | , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2010
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| 在线阅读: | https://doi.org/10.1038/cddis.2009.8 https://www.nature.com/articles/cddis20098.pdf |
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