High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

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Auteurs principaux: Benoı̂t Stijlemans, Guy Caljon, Senthil Natesan, Dirk Saerens, Katja Conrath, David Pérez‐Morga, Jeremy N. Skepper, Alexandros Nikolaou, Lea Brys, Étienne Pays, Stefan Magez, Mark C. Field, Patrick De Baetselier, Serge Muyldermans
Format: Artigo
Langue:anglais
Publié: 2011
Accès en ligne:https://doi.org/10.1371/journal.ppat.1002072
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002072&type=printable
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https://doi.org/10.1371/journal.ppat.1002072
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002072&type=printable

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