High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis
The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...
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| 主要な著者: | , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | 英語 |
| 出版事項: |
2011
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| オンライン･アクセス: | https://doi.org/10.1371/journal.ppat.1002072 https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002072&type=printable |
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