Endosomes generate localized Rho–ROCK–MLC2–based contractile signals via Endo180 to promote adhesion disassembly
The regulated assembly and disassembly of focal adhesions and adherens junctions contributes to cell motility and tumor invasion. Pivotal in this process is phosphorylation of myosin light chain-2 (MLC2) by Rho kinase (ROCK) downstream of Rho activation, which generates the contractile force necessa...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2006
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| 在线阅读: | https://doi.org/10.1083/jcb.200602125 |
| 标签: |
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