Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl(4)) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts. When the underlying etiological agent is removed, clinical and experimental fibrosis undergoes a r...

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Autori principali: Tatiana Kisseleva, Min Cong, Yong‐Han Paik, David Scholten, Chunyan Jiang, Christopher Benner, Keiko Iwaisako, Thomas Moore‐Morris, Brian T. Scott, Hidekazu Tsukamoto, Sylvia Μ. Evans, Wolfgang Dillmann, Christopher K. Glass, David A. Brenner
Natura: Artigo
Lingua:inglese
Pubblicazione: 2012
Accesso online:https://doi.org/10.1073/pnas.1201840109
https://www.pnas.org/content/pnas/109/24/9448.full.pdf
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