P-Glycoprotein Mediates Efflux Transport of Darunavir in Human Intestinal Caco-2 and ABCB1 Gene-Transfected Renal LLC-PK1 Cell Lines
Darunavir (DRV) is a nonpeptidic protease inhibitor (PI) approved for the treatment of human immunodeficiency virus (HIV) infection. DRV displays potent activity against HIV strains resistant to other available PIs. Coadministration with ritonavir (RTV) improves the oral bioavailability of DRV. Inhi...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2009
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| 在線閱讀: | https://doi.org/10.1248/bpb.32.1588 https://www.jstage.jst.go.jp/article/bpb/32/9/32_9_1588/_pdf |
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