Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008
Paired homologs of γ-butyrolactone (GBL) biosynthesis gene afsA and GBL receptor gene arpA are located at different positions in genome of Streptomyces hygroscopicus 5008. Inactivation of afsA homologs dramatically decreased biosynthesis of validamycin, an important anti-fungal antibiotic and a crit...
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| Main Authors: | , , , , |
|---|---|
| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2014
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| 在线阅读: | https://doi.org/10.1016/j.ymben.2014.12.003 |
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