The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading
Heparin-binding epidermal-like growth factor (HB-EGF) is synthesized as a transmembrane precursor (HB-EGFTM). The addition of phorbol ester (PMA, phorbol 12-myristate 13-acetate) to cells expressing HB-EGFTM results in the metalloproteinase-dependent release (shedding) of soluble HB-EGF. To analyze...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Language: | English |
| Published: |
1999
|
| Online Access: | https://doi.org/10.1074/jbc.274.40.28828 http://www.jbc.org/article/S0021925819521202/pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|