Weighting in sequence space: a comparison of methods in terms of generalized sequences.

Four methods for weighting aligned biological sequences have recently appeared that differ mathematically, philosophically, and in their results. Thus, while there is consensus about the need to weight sequences, the method to use is contentious. A geometric analysis based on a continuous sequence s...

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Bibliographic Details
Main Authors: Martin Vingron, Peter R. Sibbald
Format: Artigo
Language:English
Published: 1993
Online Access:https://doi.org/10.1073/pnas.90.19.8777
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