BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death
BIK, a pro-apoptotic BH3-only member of the BCL-2 family, targets the membrane of the endoplasmic reticulum (ER). It is induced in human cells in response to several stress stimuli, including genotoxic stress (radiation, doxorubicin) and overexpression of E1A or p53 but not by ER stress pathways res...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Englisch |
| Veröffentlicht: |
2005
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| Online-Zugang: | https://doi.org/10.1074/jbc.m500800200 http://www.jbc.org/article/S0021925820674385/pdf |
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