A New Paradigm for DNA Polymerase Specificity
We show that T7 DNA polymerase exists in three distinct structural states, as reported by a conformationally sensitive fluorophore attached to the recognition (fingers) domain. The conformational change induced by a correct nucleotide commits the substrate to the forward reaction, and the slow rever...
Guardat en:
| Autors principals: | , |
|---|---|
| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
2006
|
| Accés en línia: | https://doi.org/10.1021/bi060993z |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|