Tumor Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary Epithelial Cells
Alterations in DNA methylation are important in cancer, but the acquisition of these alterations is poorly understood. Using an unbiased global screen for CpG island methylation events, we have identified a non-random pattern of DNA hypermethylation acquired in p16-repressed cells. Interestingly, th...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2006
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| Online adgang: | https://doi.org/10.1074/jbc.m604175200 http://www.jbc.org/article/S0021925818951707/pdf |
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