Analysis of Complement Expression in Light-Induced Retinal Degeneration: Synthesis and Deposition of C3 by Microglia/Macrophages Is Associated with Focal Photoreceptor Degeneration

Purpose.: To investigate the expression and localization of complement system mRNA and protein in a light-induced model of progressive retinal degeneration. Methods.: Sprague-Dawley (SD) rats were exposed to 1000 lux of bright continuous light (BCL) for up to 24 hours. At time points during (1–24 ho...

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Main Authors: Matt Rutar, Riccardo Natoli, Peter Kozulin, Krisztina Valter, Paul A. Gatenby, Jan Provis
格式: Artigo
语言:英语
出版: 2011
在线阅读:https://doi.org/10.1167/iovs.10-7119
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