Metabolic engineering of <i>Escherichia coli</i> for the production of <scp>l</scp> -valine based on transcriptome analysis and <i>in silico</i> gene knockout simulation
The l -valine production strain of Escherichia coli was constructed by rational metabolic engineering and stepwise improvement based on transcriptome analysis and gene knockout simulation of the in silico genome-scale metabolic network. Feedback inhibition of acetohydroxy acid synthase isoenzyme III...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2007
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| 在线阅读: | https://doi.org/10.1073/pnas.0702609104 |
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