Loss of Methyl-CpG–Binding Domain Protein 2 Enhances Endothelial Angiogenesis and Protects Mice Against Hind-Limb Ischemic Injury

Loss of Methyl-CpG–Binding Domain Protein 2 Enhances Endothelial Angiogenesis and Protects Mice Against Hind-Limb Ischemic Injury

Background— Despite intensive investigation, how DNA methylation influences endothelial function remains poorly understood. We used methyl-CpG–binding domain protein 2 (MBD2), an interpreter for DNA methylome–encoded information, to dissect the impact of DNA methylation on endothelial function in bo...

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Main Authors: Xiaoquan Rao, Jixin Zhong, Shu Zhang, Yushan Zhang, Qilin Yu, Ping Yang, Mong-Heng Wang, David Fulton, Huidong Shi, Zheng Dong, Dao Wen Wang, Cong‐Yi Wang
Format: Artigo
Language:English
Published: 2011
Online Access:https://doi.org/10.1161/circulationaha.110.966408
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https://doi.org/10.1161/circulationaha.110.966408

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