A New Series of Small Molecular Weight Compounds Induce Read Through of All Three Types of Nonsense Mutations in the ATM Gene

A New Series of Small Molecular Weight Compounds Induce Read Through of All Three Types of Nonsense Mutations in the ATM Gene

Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. Despite the promise of this approach, only a few read-through compounds (RTCs) have been discovered to date. These include aminoglycosides (...

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Hlavní autoři: Liutao Du, Michael E. Jung, Robert Damoiseaux, Gladys C. Completo, Francesca Fike, Jin‐Mo Ku, Shareef Nahas, Cijing Piao, Hailiang Hu, Richard A. Gatti
Médium: Artigo
Jazyk:angličtina
Vydáno: 2013
On-line přístup:https://doi.org/10.1038/mt.2013.150
https://www.cell.com/article/S1525001616319992/pdf
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https://doi.org/10.1038/mt.2013.150
https://www.cell.com/article/S1525001616319992/pdf

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