A New Series of Small Molecular Weight Compounds Induce Read Through of All Three Types of Nonsense Mutations in the ATM Gene
Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. Despite the promise of this approach, only a few read-through compounds (RTCs) have been discovered to date. These include aminoglycosides (...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2013
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| 在线阅读: | https://doi.org/10.1038/mt.2013.150 https://www.cell.com/article/S1525001616319992/pdf |
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