Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State
The ribosome is centrally situated to sense metabolic states, but whether its activity, in turn, coherently rewires transcriptional responses is unknown. Here, through integrated chemical-genetic analyses, we found that a dominant transcriptional effect of blocking protein translation in cancer cell...
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| Main Authors: | , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2013
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| 在線閱讀: | https://doi.org/10.1126/science.1238303 |
| 標簽: |
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